Abstract: Objective: To explore the malignant signs of breast masses by conventional ultrasound （US） and to evaluate the
diagnostic efficiency of US integral method in differentiating benign and malignant breast masses. Methods: The US images of 120
cases of benign and malignant breast masses confirmed by pathology were analyzed retrospectively, and the value of US malignant signs
were assigned and integrated. The receiver operating characteristic curve（ROC）was applied to analyze the cut-off value of integration
method and its diagnostic efficiency. Kappa-test was used to evaluate the consistency between US integral method and pathological
diagnosis. Results: Two-dimensional morphological characteristics, Adler blood flow classification and age were significantly different
between benign and malignant groups（P <0.01）, which were malignant signs of US. When taking the score 7 as the best cut-off value
of US integral method, the diagnostic efficiency is the best（sensitivity, specificity, accuracy and Youden index were 92.20%, 92.80%,
92.50% and 0.850 respectively）; the Kappa value between US integral method and pathological diagnosis was 0.847（P < 0.01）.
Conclusion: US integral method has high diagnostic value in differential diagnosis of benign and malignant breast masses, and its
consistency with pathological diagnosis is high.

Key words: benign and malignant breast masses, conventional ultrasound, integral method, differential diagnosis